@witty-crayon-22786 and I paired on this and came up with https://github.com/Eric-Arellano/lockfile-platforms-problem/tree/main/multiple_pex__stu_proposal as an example of what he's proposing to fix this issue:

For example, w/ a pex_binary using platforms, the subset of reqs might be valid, but the superset of all your reqs might include deps without wheels, so the superset fails to resolve.

If that proposal does actually fix the issue with

platforms

, we could always use

[python-setup].resolve_all_constraints

. But there's the question of if is that desirable? @enough-analyst-54434 mentioned some users may want

--no-resolve-all-constraints

because the performance tradeoff swings that way for their repo