Is there a way in pants v1.25 to build a pex with multiple architecture dependencies (i.e. macOS and linux)? In pants v2.1.x? If this is answer in the docs, my apologies. I was not able to find the answer.

Pex and Pants have supported this from 1.x days for both. I'll link some docs .... but your Docker question implies you may want more than what Pants and Pex support. They support foreign architectures only if platform specific wheels are pre-built.

For my immediate need, all the wheels are built and in our repo. I was just imaging using Docker to run

./pants package|binary

on a linux platform and thus pull in the "correct" pre-built wheels.

A concrete example: you're building a pex_binary meant to ship to macOs and Linux and you build that both from Apple machines and from Linux machines dependeing. In that case you'd want: platforms=["macosx-10.6-x86_64-cp-36-m", "manylinux2014-10.6-x86_64-cp-36-m"] ... for example if you consistently target CPython 3.6 on both platforms.

this is a usecase that would be a truly killer app for multi-platform remoting. cc @fast-nail-55400