Okay I’ve made so much progress. I am now following @bitter-ability-32190 ‘s guide for optimizing container builds https://blog.pantsbuild.org/optimizing-python-docker-deploys-using-pants/ Where I’m at now is that a shared library isn’t discoverable that is needed for a libcamera package. Do I need to set PEX_EXTRA_SYS_PATH to configure the lb library path?

Yes, or PEX_INHERIT_PATH. Pexes are hermetic by default.